News: Etoperidone

Etoperidone

Etoperidone (Axiomin, Centren, Depracer, Etonin, Etoran, Staff, Tropene), also known as clopradone and thozalinone, is an antidepressant of the phenylpiperazine class which was introduced in Europe in 1977. It acts primarily as an antagonist of several receptors in the following order of potency: 5-HT2A receptor (36 nM) >α1-adrenergic receptor (38 nM) > 5-HT1A receptor (85 nM) >α2-adrenergic receptor (570 nM); it has only very weak or negligible affinity for blocking the following receptors: D2 receptor (2,300 nM) > H1 receptor (3,100 nM) > mACh receptors (>35,000 nM).